Axon reflex-mediated vasodilation is reduced in proportion to disease severity in familial amyloid polyneuropathy

Methods Twenty-one subjects were contacted to participate in this study. Eleven FAP patients and 10 normal volunteers were recruited for this hospital’s ethics committee approved study. Confirmed genetically FAP patients were recruited from our registry, and were prospectively re-examined to determine the frequency of neuropathic motor, sensory, and autonomic symptoms and findings, to measure nerve conduction parameters, and to assess thermal testing performed using a Medoc TSA-II thermal analyzer. LDIflare areas were induced by iontophoresis (at 100uA for 1 min) of histamine at the forearm and at the leg.